A total of 42 migrants are reported to have drowned overnight in two separate shipwrecks in the Aegean Sea.
One boat went down off the coast of the small Greek islet of Kalolimnos, killing 34 people, including 11 children.
Another eight people died after a boat sank off the island of Farmakonisi.
Over a million migrants arrived in Europe illegally last year. More than 700 died in the Aegean crossing from Turkey to Greece.
At least another 100 have died in the Aegean this year.
German Chancellor Angela Merkel is on Friday meeting Turkish Prime Minister Ahmet Davutoglu in Berlin to discuss the crisis.
Cabinet ministers from both countries will be in attendance.
On Thursday, French Prime Minister Manuel Valls warned that Europe’s migration crisis was putting the European Union at grave risk.
Mr Valls told the BBC that Europe could not take all the refugees fleeing wars in Iraq or Syria. If it did, he said, it could “destabilise our societies”.
The Greek coastguard said it had rescued 26 people from the sinking of the wooden sailboat off Kalolimnos, but that it had recovered 34 bodies – 16 women, 11 children and seven men.
It was not known how many people were on the boat, but some estimates said up to 100, and a search is continuing for more survivors.
The boat off Farmakonisi was carrying 48 people. Forty made it to shore and one girl was rescued, but the bodies of six children and one woman were found.
BBC Europe correspondent Damian Grammaticas says the cold and the dangers do not appear to be deterring refugees from trying to reach Europe – more than 30,000 have made such crossings to Greece already this year.
Turkey is home to nearly three million refugees, most of them from Syria.
Many of them pay smugglers thousands of dollars to make the crossing to Greece. They then head north, trying to reach Germany and Scandinavia.
Mrs Merkel is meeting Mr Davutoglu amid mounting pressure to rethink Germany’s open-door policy and impose caps on its refugee intake.
Mr Valls appeared to suggest her current message was wrong in his interview with Lyse Doucet, the BBC’s chief international correspondent.
Although he said Mrs Merkel “had courage”, he added: “A message that says ‘Come, you will be welcome’ provokes major shifts” in population.
He added: “We know clearly that after the Cologne incidents that with the continuous flow, not only to Germany but the countries of Northern Europe, Austria, the Balkans are confronted with this influx, that’s why we need to find practical solutions for our borders.”
Mr Valls was referring to attacks in the German city on New Year’s Eve – largely attributed to foreigners – that have sparked 800 complaints, 520 of them relating to sexual crimes.
EU countries hope Turkey will help to control the flow of migrants.
Mrs Merkel has urged the EU to honour its pledge of €3bn euros ($3.3bn) to improve conditions for refugees living there.